Further developing a genre begun by Nicholas Kallikles, he wrote many occasional poems for a widespread circle of patrons at the Byzantine court.
Despite the panegyric and conventional treatment, his writings, often produced on some public occasion, provide important information on many aspects of contemporary Byzantine history.
There is a strongly satirical vein in his works, which range from epigrams and dialogues to letters and occasional pieces in both prose and verse.
Taking example by Heliodorus of Emesa's Aethiopica, he wrote a novel in verse, Rhodanthe and Dosikles (Τὰ κατὰ Ῥοδάνθην καὶ Δοσικλέα) in 9 books.
Prodromos also wrote numerous occasional poems and epigrams, often on the occasion of some public event of historical significance, or for the purpose of begging for something; a few religious poems and treatises on the topics of theology, philosophy and grammar; dialogues written in the style of Lucian of Samosata; a hagiography of Saint Meletios the Younger; occasional speeches, epistles and many other writings.
The evidence was found in one verse among the Ptochoprodromic writings, where the author praises the "famous writer, harmonious swallow", who was his "friend and predecessor".
The poem C, addressed to emperor Manuel I Komnenos (r. 1143–1180), relates a young monk's complaint over scandalous living circumstances in his monastery.