[2] Thioridazine was voluntarily discontinued by its manufacturer, Novartis, worldwide because it caused severe cardiac arrhythmias.

[9] Generic forms of thioridazine remain on the market in a few countries, usually with restrictions due to the risk of arrhythmias.

[17] Thioridazine has been correlated to rare instances of clinically apparent acute cholestatic liver injury.

[23] The manufacturer Novartis/Sandoz/Wander of the brands of thioridazine, Mellaril in the US and Canada and Melleril in Europe, discontinued the drug worldwide in June 2005.

[2][4] Generic forms of thioridazine however remain on the market in a few countries usually with restrictions for example in the US its restricted to patients who have taken at least 2 other antipsychotics that either failed or caused serious side effects [10] Thioridazine is known to kill extensively drug-resistant tuberculosis[24][25] and to make methicillin-resistant Staphylococcus aureus sensitive to β-lactam antibiotics.

[25] The drug has been successfully used in the treatment of granulomatous amoebic encephalitis in conjunction with more conventional amoebicidal medications.