Thiosemicarbazone

Many variations exist, including those where some or all of the NH centers are substituted by organic groups.

Thiosemicarbazones are usually produced by condensation of a thiosemicarbazide with an aldehyde or ketone: In terms of their chemical structures, the CSN3 core atoms are coplanar.

[1] Some thiosemicarbazones have medicinal properties, e.g. the antiviral metisazone and the antibiotic thioacetazone.

Thiosemicarbazones are also widely used as ligands in coordination chemistry.

[2] The affinity of thiosemicarbazones for metal ions is exploited in controlling iron overload.