[1] It was formerly called Kentucky Street in the Dogpatch and Railroad Avenue in the Bayview.

[2] Major League Baseball's San Francisco Giants play at Oracle Park on the intersection Third and King.

It is also the first true light rail line in the mostly streetcar Muni Metro system, as it operates primarily in the median.

In the 1960s, the downtown section of Third Street was known as San Francisco's "skid row", with most of its (then much smaller) homeless population concentrating there.

[7] The street featured as a filming location in the James Bond film A View to a Kill, when Bond escapes from police in a fire engine by jumping over the rising Lefty O'Doul Drawbridge.