The 12641 / 12642 Thirukkural Express is a superfast express train in India, running between Kanniyakumari in Tamil Nadu which is the southernmost tip of the Indian Subcontinent, and Hazrat Nizamuddin in New Delhi.

The train shares a common route and timetable with the Tamil Nadu Sampark Kranti Express from Hazrat Nizamuddin to Dindigul in return and from Madurai to Hazrat Nizamuddin in upward.

Thirukkural is a book of verses on common ethics and morality written by Tamil Poet Thiruvalluvar.

The train was named after the book, with the statue of Thiruvalluvar installed at Kanniyakumari The 12641 Hazrat Nizzamuddin–Thirukkural Express departs Kanniyakumari every Wednesday and Friday at 19:05 IST (07:05 PM) and reaches Hazrat Nizamuddin every Friday and Sunday 18:30 IST (06:30 PM).

The Thirukural Express is hauled by an Royapuram / Lallaguda-based WAP-7 locomotive on its entire journey.