His early interest in insanity resulted in an apprenticeship with David Skae, the eminent Superintendent of the Royal Edinburgh Asylum.
Clouston published extensively, beginning with his remarkable Clinical Lectures on Mental Diseases (1883), followed, much later, by his more popular work Unsoundness of Mind (1911).
[6] Another book aimed at the general public was entitled Morals and The Brain; and he remained an unreconstructed believer in "masturbational insanity" and an uncompromising advocate of teetotalism in opposition to his exact contemporary, the psychiatrist James Crichton-Browne.
[9] In 1894 he opened the Craig House extension to the Royal Edinburgh asylum on Easter Craiglockhart Hill, which was renamed the Thomas Clouston Clinic in 1972.
[3] He is commemorated by a brass plaque on the eastern aspect of the north transept of St Magnus Cathedral in Kirkwall.
[11] At the end of his life Clouston lived at 26 Heriot Row, an elegant and substantial Georgian townhouse in Edinburgh's New Town.