He was a priest and a member of the chapel of Emperor Charles V, but whether he was maître de chapelle or merely a singer is still a matter of dispute; the surviving documents are contradictory.
Unlike many of the composers of the Franco-Flemish school, he seems never to have left his home region for Italy or other parts of Europe.
Crecquillon's music was highly regarded by his contemporaries, and shows a harmonic and melodic smoothness which prefigures the culminating polyphonic style of Palestrina.
Unlike Josquin, however, Crecquillon rarely varies his texture for dramatic effect, preferring smoothness and consistency.
His secular chansons, unlike most of those by other composers of the same time, also use pervading imitation, although as is normal in a lighter form of music, they make considerable use of repetition (for example of the final phrase).