Thomas Henry Selby (May 14, 1820 – June 17, 1875) was an American politician and businessperson.

He moved to San Francisco, California and became a merchant in the city.

Selby died in San Francisco on June 17, 1875, of pneumonia.

He is buried in Mountain View Cemetery in Oakland, California.

His daughter, Cornelia, married Rear-Admiral Louis Kempff of Belleville, Ill.