Thomas Jefferson is accredited by Independent Schools Association of the Central States (ISACS).

[2] In the Upper School, Thomas Jefferson offers 18 Advanced Placement courses including: Biology; Chemistry; Calculus AB; Calculus BC; Computer Science, Government and Politics; English Language and Composition; English Literature and Composition; Latin: Vergil; European History, Music Theory; Physics; Spanish Language; Spanish Literature; Statistics; and U.S. History.

Thomas Jefferson is a member of the Missouri State High School Activities Association (MSHSAA) and competes in the Ozark 7 Conference.

[4] The school offers students the ability to participate in contests for math, writing, foreign languages, music, art, geography, and spelling.

The Upper School Vocal Ensemble was selected to be part of a 200-voice choir that would perform Faure's "Requiem" at Carnegie Hall on June 7, 2015.