[1] That week Atalanta also signed half of the registration rights of D'Agostino for €800,000,[1][2] as well as sold half of the registration rights of Marco Motta and Fausto Rossini to Udinese for €2.05 million and €450,000 respectively,[2] as well as Cesare Natali, Piermario Morosini (50%) and Massimo Gotti for undisclosed fees.

[3][4] In July 2007, he (along with three other players) were banned from football for a duration of three months as a result of illegal betting.

[citation needed] On 26 July 2010, he signed with the newly relegated Serie B side, to remain under contract until 2013 with an option to extend to 30 June 2014.

In January 2013, Manfredini left Atalanta and joined Genoa, in a swap deal involving 50% registration rights of Michele Canini.

On 30 June 2015, Vicenza signed Manfredini outright in a two-year contract, with Giovanni Sbrissa and became a player of Sassuolo in 2016–17 season.