Morosini, then a sub-deacon, was elected patriarch by the Venetians immediately after the sack of Constantinople by the Fourth Crusade and the establishment of the Latin Empire.
At first, his election was contested as uncanonical by Pope Innocent III.
His relationship to the court of the Latin emperor Henry of Flanders was strained due to questions of jurisdiction, accusations of embezzlement from the treasury of the Hagia Sophia, and chiefly due to Morosini's exclusive promotion of Venetian clergy to higher ecclesiastical offices.
He also failed to reconcile the Orthodox Byzantine Greeks, both clergy and people, to Catholic rule; instead, they transferred their allegiance to the Empire of Nicaea.
After his death, the see remained vacant until the election in November 1215 of Bishop Gervasius (Gervais) of Heraclea Pontica.