In Spring 1578 Muffet boarded with Felix Platter, chief physician of Basel, where he adopted the Paracelsian system of medicine.

The year after receiving his MD, in 1580, Thomas Muffet studied silkworm anatomy in Italy before finally returning to England.

This was not expected, as Muffet was a strong advocate for the Paracelsian system of medicine, which was not widely respected by the medical community.

The same year, Muffet was sent by Sir Francis Walsingham on a diplomatic mission to Denmark to present the Order of the Garter to King Frederick.

That same year, Muffet wrote a letter attacking the London College of Physicians for Papist influences through the lens of his own Puritan beliefs.

Thomas Muffet first studied silkworms while working in Italy, beginning his continued fascination with arthropods in general, particularly spiders.

The book contained significant contributions by three other scientists, the Swiss Conrad Gessner[1] alongside Edward Wotton and Thomas Penny.

[6] Muffet's work in nutrition was collected in his book Health's Improvement which was designed more for the layman than for contemporary medical professionals.