Thomas Nairne (died c. 17 April 1715) was a Scots trader and the first Indian agent of the Province of Carolina.
After arriving in South Carolina, Nairne became a representative of the House of Commons Assembly for Colleton County in 1707.
During this period, Thomas Nairne arrested Governor Nathaniel Johnson's son on charges of enslaving friendly Indians and illegally stealing deerskins.
Governor Johnson charged Nairne with treason, and he was forced to return to England to defend his actions.
Neither the French nor the English amassed an Indian army, and they continued to maintain their respective allies through the end of Queen Anne's War.