Prince is the Ira S. Bowen Professor of Physics at the California Institute of Technology[1] and holds a joint appointment with Caltech’s NASA Jet Propulsion Laboratory (JPL) as a senior research scientist.

Detection and study of neutron stars and black holes has been a continuing theme in Prince's research, starting with his gamma ray observations of compact objects in the Galactic Center region.

He participated in several expeditions to the Australian outback in the late 1980s to make balloon observations of the radioactive decay energy from Supernova 1987a.

Starting in the late 1990s, Prince began to work on development of techniques for detection of gravitational waves from neutron star and black hole systems.

Most recently, Prince has been using the Palomar Transient Factory to carry out time-domain studies of astronomical sources, including ultra-compact binaries.