[1] His early marriage has been considered a contribution to the use by Jane Austen of amateur theatricals as a plot device in her novel Mansfield Park.
He was educated at Westminster School, where he was a scholar, played cricket and other sports, and participated in The Trifler, a periodical, with John Hensleigh Allen and others.
[6] Twisleton's first marriage was at age 18 or 19, the result of an elopement with the heiress Charlotte Anne Frances Wattrell.
[3][7][8] Twisleton already had acting experience, in theatricals at Adlestrop House, and the couple performed together, there and elsewhere, for a year or so, attracting public attention.
[8] Surviving issue of the marriage was the daughter Julia Eliza (1789–1832), who married Captain James Brown in 1808.