[3] As early as 1630, a trading post was established on the eastern bank of the St. George River, then considered the boundary between New England and New France.

In 1704, Thomas LeFebvre from Quebec bought a large tract of land along the Weskeag River on which he built a gristmill, with a house on the shoreline at what is now South Thomaston.

Instigated by the French, they attacked the garrison twice during Dummer's War in 1722, then again in 1723 with a siege lasting 30 days.

Located at the heart of the Waldo Patent, Thomaston was incorporated from St. Georges Plantation on March 20, 1777.

[9] Other industries included two gristmills, two sawmills and planing mills, three sail lofts, brickyards, cask manufacturing and a marble works.

[10] Thomaston is still home to Jeff's Marine, Inc. and Lyman Morse Boatbuilding, builders of custom power and sailing yachts.

Located on St. George River, Lyman Morse Boatbuilding sits on the original site of the General Henry Knox Mansion, where wooden schooners have been built for over 200 years.

[10] In June 1875, Louis Wagner, the Smuttynose Axe Murderer, and John True Gordon, known as the Thorndike Slayer, were hanged on the gallows of the then-Maine State Prison in Thomaston.

Louis Wagner's burial site was unknown until the book Return to Smuttynose Island: And Other Maine Axe Murders by Emeric Spooner was released in 2009.

[11] Thomaston was home to the Maine State Prison until 2002, when it moved to Warren and the former facility was demolished.

Today, Thomaston is a resort area with a large historic district containing Federal, Greek Revival and Italianate architecture.