[1] After the arrival of the railroad in 1855, Dr. Elijah Thompson donated land for a town and train station, and the community was renamed for him.

[1] On March 5, 1863, during the Civil War, the Battle of Thompson's Station was fought, with Confederate forces led by General Earl Van Dorn defeating Union forces under Colonel John Coburn.

The Town includes several parks that encompass over 200 acres (81 ha):[9] The community voted to incorporate in August 1990 with resident David Lee Coleman chosen as the first mayor.

[10] In early 2015, the Town embarked on a city planning process to update the zoning regulations.

After gathering public input, the Town worked with planning consultants to create the Land Development Ordinance that went on to receive the Driehaus Award's Honorable Mention for form-based code in 2016.

Due to quick growth, another special census was taken in October 2016 with a newly certified population of 4,726.

[15] The 2020 Federal Census population results for Thompson's Station show the Town has grown to 7,485 residents.