Thompson Creek is a 6.8 mile (11.0 km) 3rd order tributary to Oil Creek that rises on the Caldwell Creek divide in Crawford County, Pennsylvania.

According to the Geographic Names Information System, it has also been known historically as:[1] Thompson Run rises on the Caldwell Creek divide about 0.5 miles east of Shelmadine Springs in Crawford County, Pennsylvania.

Thompson Creek then flows west to meet Oil Creek in Hydetown.

[5] Thompson Creek drains 35.9 square miles (93 km2) of area, receives about 45.4 in/year of precipitation, has a topographic wetness index of 445.85, and has an average water temperature of 7.35 °C (45.2 °F).

[3] The watershed is 53% forested.