Equally inspired by H. P. Lovecraft, Philip K. Dick, and ambient electronic music, the series ran for 63 issues (published by a number of companies) from 1985–1998, making it one of the longest-running indy comics titles.

[citation needed] The Post Bros., Ron and Russ (named for brothers Ron and Russ Mael, the duo that make up the American pop and Rock duo, Sparks) are natives of a mysterious transdimensional locality known as Bugtown, where all residents possess the ability to engage in interdimensional travel.

According to creator Howarth, the Post Bros. are "greedy, pathologically trigger-happy, completely corruptible, endlessly irritating, psychotically solipsistic and — unfortunately for all — possessed of the ability to instantly shift between all possible reality levels".

In addition, the real-world avant-garde art collective The Residents appeared in Those Annoying Post Bros.: Stalking Ralph (Aeon Press, 1995).

Beginning in 2008, Howarth wrote a number of prose novels (with no illustrations) taking place in the Bugtown universe that also featured the Post Bros.