An uptempo song with heavy bass, it began as a freestyle by Megan Thee Stallion, and was inspired by her desire to reclaim the term "thot" from men who used it in a sexist manner.

Over a month before the release of "Thot Shit", several sci-fi-themed posts on Megan Thee Stallion's social media showed her in a "regeneration tank" and announced that she would be "recharging".

Megan Thee Stallion later posted a link to pre-save the song, and revealed the release date, title, and cover of "Thot Shit", which shows a shirtless man collapsed on a checkered tile floor next to a plate of food, a magazine featuring an image of Megan Thee Stallion, and a box of "Tina O's" cereal, with three women in white patent leather platform heels standing over him.

She also references her scheduled graduation from Texas Southern University in 2021 and the 1940 film Pinocchio, and quotes the 1998 miniseries The Temptations with the line, "Ain't nobody come to see you, Otis".

Rolling Stone's Mankaprr Conteh called "Thot Shit" "a sonic and visual explosion of sexuality, pride, and ideas" filled with "sharp zingers", adding that her "tone and candor" on the song combined her "hard-hitting raps" with "the strong sense of purpose she's developed as a woman that has been attacked and vilified for her boldness and honesty".

[21] Pitchfork named the song "Best New Track", with Cat Zhang writing, "'Thot Shit' follows the classic Megan recipe: unapologetic sex positivity, brash and delicious boasts, sharp-tongued goofiness.

Club's Gabrielle Sanchez described "Thot Shit" as "charged and fast-paced, carrying the intensity last year's Good News too often lacked" with an "infectious" energy.

[24] The music video for "Thot Shit", directed by Aube Perrie and executive produced by Boris Labourguigne, was released on the same day as the single.

[7] Skip Pipo stars in the video as an older conservative senator meant to represent James P. Bradley, a Republican congressional candidate for California who, after listening to American rapper Cardi B's song "WAP" featuring Megan Thee Stallion, posted on social media that the two artists "are what happens when children are raised without God and without a strong father figure" and claimed that he came across the song accidentally.

[34][35][36] Megan Thee Stallion, who appears as her alter ego, Tina Snow, then anonymously calls the man to tell him not to "fuck with" the women who make up every part of his life in a monologue inspired by the 1999 film Fight Club.

The next shot shows Megan's alter ego and several other working-class women (the "Hotties") then hit the man with a garbage truck, and spend their time exacting revenge on him by following him around as he does mundane tasks and twerking wherever he goes, including at a diner, in his office, in his bathtub, at the supermarket, and at a construction site.

[23] For Popsugar, Navi Ahluwalia called the video "a powerful commentary on the world of online hate", while USA Today's Elise Brisco described it as "iconic" and "empowering".

[30] TechCrunch's Taylor Hatmaker called the video a "a playful but important paean to essential workers" and "a biting commentary on the wealthy white establishment that exploits their labor".