The hospital is supported by the Thunder Bay Regional Health Sciences Foundation.

Thunder Bay Regional Health Sciences Centre's emergency department is one of the busiest in Canada, receiving over 106,000 annual visits.

Patients from both hospitals were relocated on February 22 and 23, 2004, at which time the name was changed to Thunder Bay Regional Health Sciences Centre.

The centre's critical care unit, operating rooms and emergency department trauma rooms feature articulating arms, which allows physicians and caregivers to operate with greater ease.

Its construction features a three-story atrium and one of the primary structural elements is wood, for which it won an award in 2004.