Ticuantepe is a town and a municipality in the Managua department of Nicaragua with an estimated population of 39,012.

The municipality is likely named after the Nahua chiefdom of Tekwantepek which was located in the Managua department.

Located in Ticuantepe is Chocoyero Nature Reserve, which is the smallest protected area in Nicaragua at just 455 acres (1.84 km2).

There are wild howler monkeys as well as a vast array of flora and fauna and two waterfalls.

Milwaukee residents collected aid shipments for Ticuantepe during the years of the Sandinista government, with a focus on medical supplies.

After 1990, Milwaukee's aid shipments fell off as a result of the imposition of custom charges, and around 2005, the sister city relationship was discontinued.