Tilemann Heshusius (also Hesshus, Heßhusen, Hess Husen, Heshusen) (3 November 1527 in Wesel — 25 September 1588 in Helmstedt) was a Gnesio-Lutheran theologian and Protestant reformer.

He became involved in another controversy over the Lord’s Supper in Bremen, which did not redound to his glory, opposing Albert Hardenberg and Jacob Probst.

For that reason he challenged Jacob Andreae, Victorinus Strigel, Matthias Flacius and all those who pursued the cause of Lutheran unity.

In 1573, when the Elector August of Saxony took over the administration of Saxe-Weimar after the death of Duke John William, nearly 100 pastors were forced to leave the territory.

Martin Chemnitz helped him secure an influential position on the theology faculty at the newly established University of Helmstedt.

Though he had earlier opposed the union efforts of Andreae, he was finally persuaded to sign the Formula of Concord, and every obstacle to its introduction in Brunswick seemed to be removed; but in comparing the printed copy with the written text, Hesshusius found a considerable number of deviations, and was not satisfied with the explanations of Chemnitz.