Tillabéri is the regional capital; other major settlements include Abala, Ayourou, Banibangou, Bankilare, Filingué, Ouallam, Say, Téra and Torodi.

[6] The main ethnolinguistic groups are the Zarma (also referred to as 'Djerma') and Songhai with minority Tuareg, Fulani, and Hausa populations.

However, Tillabéri is rich in mineral resources (gold and iron ore) and increasingly becoming attractive for future mining investments.

In addition, the region of Tillabéri has great touristic potential with W National Park, the Niger river and many more attractions.

The W National Park, which straddles the tri-border area of Benin-Burkina Faso-Niger, is classified as a World Heritage Site by UNESCO.