His first feature, The Best Man was an $11 m romantic comedy starring Seth Green, Stuart Townsend, Amy Smart and Simon Callow and was directed by Shooting Fish director Stefan Schwartz.
In 2007 he composed the score for Ashley Judd's role as a manic depressive in the Sundance selected Helen, directed by the critically acclaimed Sandra Nettelbeck of Mostly Martha.
's The Royals, NBC's Winter Olympics campaign, the 2015 Super Bowl halftime commercial spot for Redfin, ABC's Switched at Birth, Mixology, Chasing Life, Franklin and Bash and many more.
2015 he scored Lionsgate feature length thriller Heist (dir Scott Mann) starring Robert De Niro, Kate Bosworth and Dave Baustista, along with co-composer James Edward Barker.
In 2019 it was announced that Tim Despic will be composing the score for The Courier (2020) starring Gary Oldman and Olga Kurylenko along with producer and collaborator James Edward Barker.