The lyrics discuss how Dave Grohl felt "like I wasn't entirely myself" during the three-month hiatus the Foo Fighters entered following the tense and unsatisfying first recording sessions for One by One, as well as his uncertainty about the future of the band.

The band is shown performing the song against changing backgrounds, consisting mainly of brightly colored kaleidoscopic forms similar to those found in music visualization, giving the video a psychedelic, hopeful, joyful mood.

Gradually, more and more people arrive at the bridge and start throwing other inanimate objects (including appliances, instruments, and furniture) behind and around the oblivious band members.

The actions of the participants would suggest that their motivations and intentions are to cast off the material trappings of society which prohibit them from living freely.

Two cars (a Chevrolet Camaro and an MGB) are then simultaneously dropped off the bridge and behind the band, resulting in clouds of smoke and fire.

It consists solely of clips of Grohl recording the song's vocal, guitar, and piano tracks in the studio.

The acoustic version of this song was used in episode 20 of season 4 ("The Birth and Death of the Day") of One Tree Hill during the graduation scene, which is also when Haley's water breaks.

This is also used as the theme song for a video montage showing memorable past goals at Turf Moor for all of Burnley FC's home games from 2009 to the present.

As a response to the COVID-19 pandemic in the United Kingdom, BBC Radio 1 organised the "biggest ever" Live Lounge cover version as part of their Stay at Home project.

[23] Among various charities worldwide, profits from the single will primarily go to Children in Need and Comic Relief, as well as WHO's COVID-19 Solidarity Response Fund.

[24] Within 12 hours of the song's initial release, it gained 43,000 digital downloads and entered the top 5 on the UK Singles Chart.