[7] Nastyukhin's success in Pankration made the transition to mixed martial arts seamless.
Nastyukhin was only 18-years-old at the time of his debut, and after the loss he took nearly three years away from active competition to improve his skill set.
[8] On April 8, 2013, Nastyukhin returned to action and began a seven-fight win streak that would lead to his signing to ONE Championship against Dmitry Ermolaev at Siberian League: Siberia vs. Kazakhstan.
He made an instant impact with a first-round knockout by way of a flying knee and soccer kicks in the first round.
[10][11] In the opening round of the ONE Championship Lightweight World Grand Prix on March 31, 2019, Nastyukhin was matched up with the debuting Eddie Alvarez.
He won the fight by unanimous decision and secured a title shot against ONE Lightweight World Champion Christian Lee.
[16] Nastyukhin faced Saygid Guseyn Arslanaliev in a rematch at ONE: Winter Warriors on December 3, 2021.