The differing weight placed on the tires by the front and rear axles causes uneven wear.
Front-wheel drive vehicles have not only the engine but also the transaxle in front, adding to the weight difference.
Thus, tire rotation needs to occur more frequently for front-wheel drive vehicles.
In effect the vehicle is constantly turning, causing uneven tire wear.
A rear tire blowout will cause the vehicle to become very difficult to control, especially at highway speeds.
It also greatly increases the risk of rollover due to yawing, a condition where the rear of the vehicle swings out and becomes perpendicular to the direction of travel: yawing can cause the tire to separate from the rim, leading the rim to dig into the pavement, or dirt and grass if no longer on the road, which can trip the vehicle and cause its rollover.