Guests generally include nuclear energy experts who come from various political, scientific, and business backgrounds.

Titans of Nuclear was conceived by Bret Kugelmass, founder of the Energy Impact Center in Washington, D.C., in 2017.

[4] In 2019, the podcast featured interviews with national politicians, including House Representative for Massachusetts Seth Moulton[5] and Idaho Senator Mike Crapo.

[7] Kugelmass would later begin sharing hosting duties with Jadwiga Najder, Olubunmi Olajide,[8] and Naomi Senehi.

[2] Episodes generally consist of one-on-one interviews[11] conducted by Bret Kugelmass, Jadwiga Najder, Olubunmi Olajide,[8] or Naomi Senehi[9] with guests who are experts in nuclear energy.