Humberto "Tito" Nieves was born in Río Piedras, Puerto Rico, and raised in the United States.

[2] In 1977, he teamed up with singer Héctor Lavoe and his Orchestra and joined the Conjunto Clasico.

[3] Later, Nieves started his solo career in 1986, setting himself apart by singing salsa in English.

He attended Xaverian High School in Brooklyn, New York, where he played in a Spanish-language band named Makondo.

[6] On August 12, 2021, Tito Nieves was the featured singer on Norberto Vélez's YouTube channel titled "Sesiones Desde La Loma Ep.