Her career in broadcasting started when she was about 18 years old after she joined radio comedians Andoy Balunbalunan and Dely Atay-Atayan as a group singer.
Magpayo was the last radio presenter heard on-air before DZXL was shut down after the imposition of Martial Law in 1972, however, she soon after continued to host her program, but this time over RPN's DWWW 630 kHz (now as DWPM).
[3] Magpayo also acted professionally and was a leading lady to Ángel Esmeralda, Pugo and Togo in several shows at the Manila Grand Opera House.
She was also a singer, having recorded songs for Villar Records such as Pamaypay ng Maynila ("Hand fan of Manila"), Sa ilalim ng Ilang-Ilang ("Beneath the Ylang-ylang"), Pandanggo ni Neneng ("Neneng's fandango"), "Paru-Parong Bukid" ("Butterfly from the Field") and Nabasag ang Banga ("The jar is broken").
While anchoring said radio show on the evening of August 30, 2008, she suffered a stroke and was rushed to the Manila Doctors' Hospital.
In 2006, Magpayo was presented with the Gawad Plaridel Award by the University of the Philippines for keeping her "dedication, integrity, and professionalism".