Tlapalizquixochtzin was an Aztec noblewoman and Queen regnant of the Aztec city of Ecatepec.
[1][2] She was born as a Princess – daughter of Matlaccoatzin and thus a granddaughter of the King Chimalpilli I and sister of Princess Tlacuilolxochtzin.
[2] Tlapalizquixochtzin married Aztec emperor Moctezuma II (c. 1466 – June 1520).
Their daughter was Doña Francisca de Moctezuma.
[2] Her nephew was King Diego de Alvarado Huanitzin.