Tmesiphantes yupanqui is a species of spider in the subfamily Theraphosinae of the family Theraphosidae.

[1] The species was first described in 2014 as Melloleitaoina yupanqui.

[1] The specific name yupanqui is in honour of Atahualpa Yupanqui, a famous musician and a synonym of Héctor Aramburu.

[1] Tmesiphantes yupanqui has a very curved embolus with no triangular spine, and a discontinued prolateral superior keel (still on the embolus) which separates into two keels.

The female spermathecae are short and with large granules.