The song was released for digital download and streaming by Sony Music Latin and Duars Entertainment on May 20, 2021, as the second single from the album.

A Spanish language dance-pop and electropop song, it is about a girl who drives Alejandro crazy and makes his heart race, while he confesses he likes everything about her.

The track received highly positive reviews from music critics, who complimented its fusion of genres and the singer's departure from his regular aesthetic.

The members of his team were surprised when they heard the song and Alejandro said: "I have this record, I feel it can be different, but I want to be ready with another one in case it doesn't work out."

The senior manager of Sony Music Latin John Eddie Perez stated that "with 'Todo De Ti' there was a chance it wouldn't even make the album" and although they supported Alejandro, they "were a little skeptical of how it would work out".

[5] On May 20, 2021, "Todo de Ti" was released for digital download and streaming by Sony Music Latin and Duars Entertainment as the second single from Vice Versa.

[6] According to the song's sheet music on Musicnotes.com, "Todo de Ti" is composed in the key of D♯ minor with a groove of 128 beats per minute.

[20] Lyrically, "Todo de Ti" which translates to "Everything About You" in English, is a romantic song about a girl who drives Alejandro crazy and makes his heart race, while the hopeless singer confesses he likes everything about her.

[22] Writing for Billboard, Griselda Flores gave it a positive review, noting Alejandro's "departure from his signature urban-leaning sonority" and the track's "summer anthem potential" that allows the singer to "show off not only his dancing abilities and roller-skating skills, but also his chameleonic abilities to shift gears and go from hard-core reggaeton to a sweet, groovy pop tune".

[25] Also from Billboard, Joe Lynch described it as "genre-melding",[26] Jessica Roiz called it "a phenomenon on TikTok",[2] and Jason Lipshutz labeled it "a sweaty and jubilant dance track" that "makes its listeners immediately snap to attention".

[27] NPR reviewer Anamaria Sayre called the track "awesome", labeled it "a bop", and chose it as her song of the summer, since it takes her "to the boardwalk on roller skates mentally every single time [she] listen to it".

[28] In another article, she kept praising the song for being "as energetic as it is resonant", its "danceable beats", "snappy refrain", and "Alejandro's catchy tune", while naming it "the world-sprawling welcome party for new-wave Latin pop".

[29] Rolling Stone critic Julyssa Lopez ranked "Todo de Ti" among Alejandro's 10 Essential Songs, highlighting the track's "spangled, disco-tinged arrangements" and the singer's "bright" vocals.

[30] In another article, she described the song "as shiny as a disco ball",[31] while Elias Leight from the same magazine labeled it "an unusual sound in the current Latin mainstream" that became "a massive global hit".

[16] Rolling Stone staff also named it "a world-wide hit and a star-making coup for Alejandro" and stated that it is "a pop smash that rewired reggaeton's circuitry with its transportingly buoyant New Wave synths and plush disco groove".

[39] Rolling Stone, The Fader, NPR, the Los Angeles Times, Spotify, and Amazon Music hailed "Todo de Ti" as the best Latin song of 2021.

[77] On Latin Pop Airplay, it stayed at the top for 28 weeks, making it the second longest-running number-one single on the chart in history.

It peaked at number one in Argentina,[91] Bolivia,[92] Chile,[93] Colombia,[94] Costa Rica,[95] Dominican Republic,[96] Ecuador,[97] El Salvador,[98] Guatemala,[99] Honduras,[100] Latin America,[101] Mexico,[39] Nicaragua,[102] Panama,[103] Paraguay,[104] Peru,[105] Puerto Rico,[106] and Uruguay.

"[114] On September 23, 2021, Alejandro, wearing a sleek overcoat, performed the track at the 2021 Billboard Latin Music Awards under a disco ball, while surrounded by multiple roller skaters dancing around him.

In his review for Billboard, Joe Lynch praised "the backup dancers/skaters" for their "impressive unison", while stating the singer was "no slouch either" and "busted out some seriously fancy footwork, dancing with an effortless cool that was astonishing to see".

Billboard critic Jessica Roiz described his performance as "energetic" and wrote: "In true Rauw fashion, his killer dance moves were the center of attention and had the crowd on its feet.