The manga is popular for its over-the-top gore and violence, and for the young main character and the different sex acts she partakes in.

Her reason to want to be eaten by Mr. Wolf is not even known to her, instead it's a desire that is locked deep within her consciousness.

The people of the church and disciples of God try to keep Akazukin from completing her mission to meet Mr. Wolf.

Their reason for doing this is because if Akazukin is eaten by the Wolf, it would bring along an end to the world and humankind as it exists in the present day.

Akazukin works as an organ harvester for an Italian butcher named Marco.

The police inspector noted that Akazukin killed 10 known victims in a year alone and harvested their organs.

Her current childlike form (when she was Astarte, she had a more adult body) is the end result of being thrown out from the Demon World after Bettega tricked her and stole her son.

She dies in the final pages of the story after sustaining injuries (i.e. losing her left arm and the lower half of her body) during her descent back to Earth after a confrontation with Bettega/Theos.

During their fight she realized she couldn't defeat Akazukin, so she instead decides to join forces with her.

She takes up residence at Marco's butcher shop and accompanies Akazukin on body hunting missions.

The title "artifact" is given to certain people who were failed experiments in creating an artificial host for the being Mr. Wolf.

Thanks to him, however, Astarte (as Akazukin) manages to get her memories back after she was shot in the head by Veruno.

He and his mother (still in her Akazukin form) are finally re-united nearing the end of the story, where she commands her son to eat her (this coming after Lupo kills his friends and other people in the orphanage), thus becoming a huge wolf-like beast.

As a result, Akazukin/Astarte attacks her son, saying "You do not belong here, but don't worry; Mama will take care of it"; however, Lupo begs his mother not to leave him.

She was sent to kill Akazukin, but failed and was forced to escape, but not before encountering Bettega, who blinds her.

After Akazukin gives him the slip one too many times he calls in for Vivi, a four armed professional assassin to murder her.

While watching their fight he realizes it's impossible to kill Akazukin and commits suicide.

Kisa wears wings on her arms, which are used as weapons, throwing their feathers as knives, cutting anything it touches.

He ends up being killed by Asbeel in the final chapter, this coming after several personality clashes with him.