He played college football at South Dakota and was selected by the Washington Redskins in the sixth round of the 2012 NFL draft.

Compton has also played for the Atlanta Falcons, Chicago Bears, Minnesota Vikings, New York Jets, San Francisco 49ers and Denver Broncos.

At the University of South Dakota, Compton was a three-time Great West Conference selection—honorable mention in 2009 and consecutive first team selections in 2010, 2011—and 2011 GWC Offensive Lineman of the Year.

[10] He became the starting right tackle midway through the 2014 season, after the incumbent Tyler Polumbus was benched following poor performance.

[13][14] In the 2016 season, Compton and the Falcons reached Super Bowl LI, where they faced the New England Patriots on February 5, 2017.

[19] After beginning the season as a backup, Compton was named the starting right guard in Week 11 following an injury to Brian Winters.

[21] The signing reunited Compton with San Francisco 49ers' head coach Kyle Shanahan, who previously was the offensive coordinator with the Washington Redskins and Atlanta Falcons.