Elections were held on November 2, 2010, to determine North Carolina's 13 members of the United States House of Representatives.

[9] As of 2024, this is the last time the Democrats won a majority of North Carolina's congressional districts, even though they did not win the popular vote.

[11] In 2010 Butterfield's opponent in the general election was Republican nominee Ashley Woolard, an insurance executive.

[14] John Carter, a U.S. Air Force veteran; Jerry Grimes, an assistant pastor and ethics instructor; and James Gordon Miller also sought the Republican nomination.

[25] In 2010 Etheridge's opponent in the general election was Republican nominee Renee Ellmers, a nurse.

[26] Frank Deatrich, a retired businessman; and Todd Gailas, an auto dealer, also sought the Republican nomination.

"[29] The incident went viral on the internet and cable television, and led to a spike in financial contributions to Ellmers's campaign.

[35] Sabato's Crystal Ball rated the race as "likely Democrat", citing Etheridge's fundraising advantage over Ellmers.

[46] In 2010 Jones's opponent in the general election was Democratic nominee Johnny Rouse, an employee of The Brody School of Medicine at East Carolina University.

[48] Robert Cavanaugh and Craig Weber, the latter of whom challenged Jones as a Democrat in 2006 and 2008, also sought the Republican nomination.

[58] David Burnett, the owner of a roofing company; George Hutchins, a Gulf War veteran; and Frank Roche, a former Wall Street executive, also sought the Republican nomination.

[72] In 2010 Foxx's opponent in the general election was Democratic nominee Billy Kennedy, a radio host.

[74] Keith Gardner, the owner of a medical-practice management business, also sought the Republican nomination.

[82] In 2010 Coble's opponent in the general election was Democratic nominee Sam Turner, a United Airlines pilot.

[84] Cathy Brewer Hinson, the manager of a furniture showroom building; Jon Mangin, the owner of IT Trainer Consultant and Viae Training and Consult; Jeff Phillips, a financial advisor; James Taylor, a doctor; and Billy Yow, a Guilford County commissioner, also sought the Republican nomination.

[96] In 2010 McIntyre's opponent in the general election was Republican nominee Ilario Pantano, a former U.S. Marine who killed two unarmed Iraqi prisoners in 2004.

[110] Pantano unsuccessfully sought the Republican nomination in the 7th district in 2012[111] and in 2013 became the director of the North Carolina State Division of Veterans Affairs.

[115] In 2010 Kissell's opponent in the general election was Republican nominee Harold Johnson, a sportscaster.

Lee Cornelison, an accountant and Vietnam veteran; Tim D'Annunzio, a business owner and former paratrooper; Darrell Day, a preacher; Lou Huddleston, an army officer; and Hal Jordan, a computer programmer, also sought the Republican nomination.

[138] In 2010 Myrick's opponent in the general election was Democratic nominee Jeff Doctor, a small business owner.

[143] Myrick retired rather than seeking re-election in 2012[144] and was succeeded by fellow Republican Robert Pittenger.

[146] In 2010 McHenry's opponent in the general election was Democratic nominee Jeff Gregory, a retired postmaster.

[162] In 2010 Shuler's opponent in the general election was Republican nominee Jeff Miller, a businessman.

[165] Dan Eichenbaum, an ophthalmologist; Jake Howard, a retiree; Ed Krause, an attorney; Greg Newman, the former mayor of Hendersonville; and Kenny West, an insurance agent, also sought the Republican nomination.

[173] Sabato's Crystal Ball rated the race as "Likely Democratic", citing Shuler's decisive 2008 victory.

[177] The 12th district included parts of Charlotte, Greensboro, High Point, Salisbury and Winston-Salem.

[180] In 2010 Watt's opponent in the general election was Republican nominee Greg Dority, a partner in a security firm.

[181] Scott Cumbie, who worked in the computer industry; and William "Doc" Gillenwater, a retiree, also sought the Republican nomination.

[187] In 2013 Watt was confirmed as director of the Federal Housing Finance Agency;[188] he was succeeded by fellow Democrat Alma Adams.

[191] In 2010 Miller's opponent in the general election was Republican nominee Bill Randall, a U.S. Navy retiree.