Toma Cantacuzino (b. Bucharest – December 22, 1721, Truhnovo, Russia) was a Romanian Spatharios and general in the tsarist army.
In April 1711, the Treaty of Lutsk was signed secretly between Dimitrie Cantemir and Peter the Great, following which the Principality of Moldavia sided with Russia in the anti-Ottoman struggle.
Toma Cantacuzino, who commanded the cavalry of Wallachia, openly sided with the Russians on June 11 despite Brâncoveanu's orders.
After the conquest of Braila, on July 25, 1711, Toma returned to his home in Filipeștii de Pădure, where he received the news of the conclusion of peace between the Sultan and the Tsar.
He is buried in the family crypt of his cousin, Constantin Brâncoveanu, in the church of the Saint Nicholas Monastery in Moscow.