Drawn to astrology, parapsychology, and yoga-tantric doctrines, he was active in the field of the occult and developed Archeosophy, a form of Esoteric Christianity.

In 1968, he founded the Archeosophical Society in Rome, which is still active and has several thousand members in Italy and the rest of Europe (mainly in Germany, Portugal, and France).

At the time, Palamidessi established contacts with exponents of the Hamburg Astrologic School, to whom he dedicated an article in the journal Astral Language.

[12] In the following years, he journeyed to India, Kashmir, Nepal, China, and South America, but from 1968 forth his efforts were focused on the archeosophical doctrine and to the organisation of groups of study and experimentation spread over Italy.

It holds that philosophy was born when man lost his spiritual contact with the Absolute or Arkè, that is as soon as his dialogue and life of union with God became increasingly obfuscated, fragmentary and doubtful.

Therefore Archeosophy, before being a philosophy, is continuous experimentation, deep knowledge of ourselves (gnosis), of nature and of God; it is the reinstatement in the Primordial Tradition, as a true, real and living contact with the supersensible worlds.The archeosophical ascesis aims at solving the religious problem of a correction of human life that does not rely on either one's whim or on chance, but on techniques of spiritual awakening and interior transmutation.

Out-of-body experiences (in order to have a direct, personal experience of spiritual worlds), methods of meditation on the centres of force directly linked with the three principles of the immortal Ego (such as the meditation on the heart defined by Palamidessi as cardiognosis or "inner knowledge of one's heart) and exercises of remembrance of some past lives are part of the itinerary of self-awareness and of the journey towards God.

In his treatise Tecniche di Risveglio Iniziatico (Techniques of Initiatic Awakening) (Ed.Mediterranee 1975) Palamidessi presents a program of integral ascesis where techniques of meditation on the centres of force and on the divine names on the one hand, an intense inner life devoted to transcendence, on the other and finally a cautious use of astral influences in order to determine the most convenient moments for the ascetic practices, converge on the unique purpose of granting a spiritual regeneration in a Christic sense.

Deeply interested in the mystical, theological and artistic tradition of the Eastern Orthodox Church, Palamidessi brings back to light the technique for preparing and painting a sacred icon.

By following the rules of the chromatic symbolism as well as the traditional geometry of sacred art, the artist can make of his own icon a "castle of meditation", by which he transcends the formal aspect of the image and becomes sensitive to the divine archetypes hidden behind it.