Inouye began to study homeopathic medicine with an American doctor, Mary A. Gault, who was married to a Japanese man and who ran a clinic at Nagasaki.
[4] Inouye was a delegate to the fourth world conference of the Woman's Christian Temperance Union in Toronto in 1897.
She was also appointed a medical inspector for school girls in Tokyo and taught hygiene and health classes.
[10] In 1923, she headed a relief project of women physicians responding to the 1923 Great Kantō earthquake.
[11][12] Inouye lived through World War II, though her home and belongings were destroyed: "All my pictures, books, instruments, specimens, and everything were burned to the ground through that terrible bomb," she wrote to Michigan friends in 1948.