The book starts in approximately the year 2020 and follows the protracted adventures of Drake Merlin, in his quest to save his wife from a terminal brain disease, over the course of eons.

Human civilization alters radically over the eons, but Ana's mangled brain proves an extremely difficult problem.

Eventually, in the extremely remote posthuman future a few billion years later, Drake's original biological body has disintegrated, despite the cryogenic treatment, and he has become an uploaded consciousness, though still in stasis.

At this point the descendants of humanity have colonized the entire Milky Way galaxy, yet an inexplicable threat is wiping out their colonies in a widening arc.

The main problem is that the beings have no idea what is happening because the planets wiped out seem exactly the same, but they do not respond to signals, and outside communication is impossible.

Finally, the collective version of Drake resolves to use the Omega Point to gain complete knowledge of everything and to restore Ana.

The story ends on an ambiguous note as Ana is potentially revived, and they seek to create a new universe by means of the caesura to live in.