Tonic water

As early as the 17th century the Spanish used quinine from the bark of Cinchona trees to treat malaria after being shown the remedy from the Indigenous peoples of Peru, Bolivia, and Ecuador.

[6] In 1868, the first known record of a gin and tonic was in the Oriental Sporting Magazine and was described as a refreshing cocktail for spectators of horse racing, not as a medicine.

Some manufacturers also produce diet (or "slimline") tonic water, which may contain artificial sweeteners, such as aspartame.

[10] Until about 2010,[11] quinine was often recommended as a relief for leg cramps, although medical research suggested some care was needed in monitoring doses.

[14] Tonic water is known to cause fixed eruptions, which is a type of skin reaction to drugs,[15] due to the quinine content.

Some symptoms of fixed eruptions include pigmented macules, high fever, erythematous plaques, and bullae.