Graffanino was primarily a contact hitter (just 481 strikeouts in 2787 big-league at-bats) who was able to get on base (career .336 OBP).

After spending three years with the Atlanta Braves, 2+1⁄2 seasons with the Tampa Bay Devil Rays, and another 3+1⁄2 with the Chicago White Sox, Graffanino played only second base for the Kansas City Royals in 2004, but moved around more in 2005.

Obtained by the Boston Red Sox for Chip Ambres and Juan Cedeño after the All-Star Game,[1] he started at second base following the cut of Mark Bellhorn.

He made an error in the fifth inning of Game Two of the 2005 American League Division Series which led to three unearned runs.

He hit .268 in 69[3] games for the Royals before being traded to the Milwaukee Brewers at the 2006 All-Star Break for left-handed pitcher, Jorge De La Rosa.

In 2002, he coordinated and led baseball clinics for boys and girls from Mercy Home at U.S. Cellular Field and signed autographs at the James R. Thompson Center to promote the need for organ donors.