After playing college football for Arkansas, he was selected by the Indianapolis Colts in the second round of the 2007 NFL draft.
During his career he started 35 of 43 games and was chosen as a third-team All-America by the Associated Press and first-team All-Southeastern Conference as a senior.
[6] On December 10, 2010, the Lions worked Ugoh out[7] and then signed him the next day to take the roster spot of linebacker Isaiah Ekejiuba, who was placed on injured reserve due to a knee injury.
[8] Ugoh's signing was seen as insurance if starting right tackle Gosder Cherilus was unable to play in the Lions' week 14 game against the Green Bay Packers due to a knee injury.
On December 7, 2011, the New York Giants signed Ugoh as a free agent, after placing Stacy Andrews on injured reserve.