A deadly tornado outbreak severely impacted the Southern United States, and also affected Iowa and Nebraska to a lesser extent, between November 27–30, 2016.

On November 28, the Storm Prediction Center (SPC) issued an Enhanced risk of severe weather for Louisiana and Mississippi.

Hail and winds battered Mississippi, and several EF1 tornadoes caused minor to moderate damage in rural areas of the state.

An EF2 tornado touched down over Monte Sano Mountain in eastern Huntsville, snapping and uprooting many trees, and damaging numerous homes as it passed through several subdivisions, a few of which had roofs torn off.

An EF3 tornado passed near the towns of Danville and Neel, causing major structural damage to industrial buildings, homes and a fire station.

A high-end EF2 tornado struck Athens, destroying several businesses and manufactured homes, heavily damaging a large church complex, and injuring 20 people.