The SPC noted uncertainty regarding convective development farther south across southwestern Kansas into Oklahoma but mentioned that any thunderstorms would be capable of significant severe weather if they came to fruition.

Strong mid- and upper-level winds associated with this feature spread across much of Oklahoma and Texas, accompanied by dewpoints in the upper 60s to lower 70s °F and mixed-layer CAPE values on the order of 2,500–3,500 J/kg.

[19] Strong southeasterly surface winds ahead of this convection in Texas provided the impetus for prolific tornado production over subsequent hours as it moved toward the northeast.

Characterized by extreme instability and low-level shear, along with a wind profile supporting the development of numerous widely spaced discrete supercell thunderstorms, conditions in place across this region were remarkably favorable for a large outbreak of violent, long-tracked tornadoes.

[38] Later that evening, a large EF2 wedge tornado touched down near Canadian, Texas, snapping numerous trees and power poles, and destroying sheds and oil field equipment.

An EF1 tornado struck the town of Marysville, Kansas, where trees and power lines were downed, a semi-truck was overturned, a few structures were damaged, and several gas tanks were thrown across a roadway.

[24] As persistent southwesterly mid-level flow continued to engulf the Central Plains, the SPC once again warned of the potential for widespread severe weather, outlining the Texas Panhandle, western Oklahoma, and southern Kansas in an enhanced risk.

[40] Thunderstorms began developing along the dryline in eastern New Mexico and western Texas around noon local time, though these storms were not tornadic in nature in the absence of strong low-level shear.

[43] Several weak tornadoes also occurred across the Ohio Valley, where a well-defined shortwave trough combined with abundant moisture and sufficient instability to produce supercell thunderstorms.

At 10:28 p.m. CDT, a low-end EF3 tornado embedded in the squall line moved through southern sections of El Reno, Oklahoma, causing severe damage, killing two people and injuring 29 others.

Several days of convection had eroded the elevated mixed layer throughout the region, but broad and intensifying southwesterly flow across northern Mexico was expected to reinvigorate this plume.

[50][51] Later in the day, a cluster of storms formed across portions of Nebraska and Kansas,[52] with a severe squall line taking shape farther south across the Texas and Oklahoma panhandles as stronger upper-level winds arrived.

By 2000 UTC the SPC had downgraded the forecast for significant tornadoes to 10%, but this time including Kansas City as the risk was shifted southward due to a stubborn cold front to the north.

Later that evening, a large EF4 wedge tornado grazed the southeastern edge of Lawrence, Kansas, before impacting the western fringes of Linwood, destroying numerous homes and agricultural buildings, debarking and denuding many trees, and injuring 18 people.

Farther along the path, the tornado weakened to high-end EF2 strength as it crossed Moreau Ridge Lane and Hohm Way, tearing the roof and exterior walls from a house and obliterating several outbuildings.

The tornado proceeded to cross Ellis Boulevard, heavily damaging multiple self-storage buildings, a gas station, a Sonic Drive-in, a church, and several other businesses.

The tornado quickly regained EF2 intensity as it tore directly down Jackson Street, snapping numerous trees and power poles and ripping the roofs off of dozens of homes.

The historic Missouri State Penitentiary sustained severe roof damage and had many windows blown out, and a portion of the large stone wall surrounding the facility collapsed.

A 300-foot cell tower was toppled to the ground, several homes sustained partial to total roof loss, outbuildings and power poles were damaged, and a large swath of trees was flattened as the tornado moved through a wooded area.

[76] The tornado reached high-end EF3 strength as it impacted the eastern part of Trotwood and exited town, inflicting major structural damage as it struck the historic Hara Arena building.

Widespread destruction occurred along North Dixie Drive and Wagner Ford Road as gas stations, hotels, churches, industrial buildings, and numerous homes and business were damaged or destroyed.

A small used car dealership was leveled, Grafton Kennedy Elementary School sustained loss of its roof and several exterior walls, and many trees were snapped and denuded in this area.

[85] Just east-southeast of this point, the tornado briefly weakened slightly as it struck a neighborhood along the west side of Grange Hall Road, where dozens of homes were heavily damaged or destroyed at high-end EF2 intensity.

The tornado then intensified back to low-end EF3 strength as it crossed Grange Hall Road, and began moving along a more due-easterly path as it tore through the Fairfield Lakes apartment complex.

The most severe damage at this location was noted along Anna Laura Lane, where multiple well-built apartment buildings sustained roof loss and collapse of their top floor exterior walls.

Continuing to the east, the tornado weakened again as it entered the Spicer Heights neighborhood of Beavercreek at EF2 strength, where numerous homes had their roofs torn off, and a few sustained some exterior wall failure.

Many restaurants and businesses including National Tire and Battery, Mike's Carwash, Primanti Brothers, Abuelos's, IHOP, Chick-fil-A, Aldi, two strip malls, and several office buildings sustained significant damage.

[86][24] On the evening of May 28, this massive, violent, multiple-vortex, rain-wrapped wedge tornado touched down at the north side of Lone Star Lake in Douglas County, Kansas.

Storm spotters reported multiple vortices with this tornado in this areas, many trees were denuded and debarked, and large amounts of debris was strewn through open farm fields.

The tornado then passed just north of Linwood and crossed 198th street, completely destroying numerous large metal agricultural buildings, as well as flipping and tossing multiple vehicles.