The present structure is located in the center of the city's old town.

Its construction began in 1347 on the remains of a previous Romanesque cathedral.

[1] The church is constructed in the Catalan Gothic style, though the façade, from the 18th century, is Baroque.

The Cathedral was the location of the famous Disputations of Tortosa, where Jews were forced to defend their faith or convert.

After two weeks of arguments, a Papal Bull was issued by the Antipope Benedict XIII that forbade the learning from the Talmud or any other Jewish book that attacked Christianity.