Drexel currently competes as a member of the Colonial Athletic Association (CAA) and plays its home games at Vidas Field in Philadelphia, Pennsylvania.

[4] Drexel's first USILA All-American was Ray Greene, who after serving in World War II transferred to Johns Hopkins, where he became a Hall of Fame midfielder.

Through the 1950s, highlights included Drexel reaching as high as number six in the standings in 1952, finishing the year with a five and two record.

In 2014, Drexel scored in the third overtime as the Dragons came back from a three-goal deficit with five minutes to go in the game, to defeat Hofstra 11–10, win its first Colonial Athletic Association championship and earn their first NCAA tournament berth in lacrosse.

Drexel was the first Pennsylvania based Division I college team to advance past the first round of the NCAAs since Penn reached the Final Four in 1988.