Toxic Crusaders refers to three separate side-scrolling video games released in 1992 which are all based on the American cartoon series Toxic Crusaders (1991) and Troma Entertainment's 1984 film The Toxic Avenger.

The Nintendo Entertainment System version was developed by Tose, the Game Boy version by Realtime Associates, and the Genesis/Mega Drive version by Infogrames.

A Super NES version was planned by Bandai, but it was not released.

[1] A new Toxic Crusaders game was scheduled for release in 2023, but as of February 2025, it has not been released.

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