It was loosely based, in that respect, on Kaufman and James Gunn's book All I Need to Know about Filmmaking I Learned from the Toxic Avenger.
In addition to the typical trials and travails of a Troma set, the crew is preyed upon by a sexually conflicted, bomb-toting serial killer.
The 'Morton Springer Show' sequence was based on the experience Lloyd Kaufman had on the Morton Downey Jr.
[1][2] The end credits states, "A VERY SPECIAL THANK YOU TO: The New York City Police Department, for their unstinting cooperation and invaluable help throughout every part of this production."
The movie includes songs from notable punk bands, including NOFX (Stranger than Fishin'), the Vandals (Idea for a Movie), Bouncing Souls (Argyle), Blood for Blood (My Time is Yet to Come), Anti-Flag (Someone's Gonna Die Tonight), and The Melvins (Horn Bearer).